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Amitriptyline vs nortriptyline for interstitial cystitis In a randomised, placebo-controlled, double-blind, parallel group trial, 11 patients with recurrent and painful interstitial cystitis were randomly assigned to receive either nortriptyline 4mg twice daily (n=8) or amitriptyline 8mg twice Pfizer viagra online pharmacy daily (n=6). The primary endpoint of this trial was to compare the efficacy of nortriptyline and amitriptyline in reducing inflammatory symptoms during cystitis. The primary safety assessment included changes in the inflammatory bowel disease score, pain, and the interstitial cystitis score over first 12 weeks of treatment, and the primary efficacy assessment, which assessed the change in inflammatory bowel disease score, pain, and the interstitial cystitis score over last 12 weeks of treatment. The mean change in inflammatory bowel disease score over the first 12 weeks of treatment was 0.17 (95% CI 0.05 to 0.33), and the Buy atomoxetine uk mean change in inflammatory bowel disease score over the last 12 weeks of treatment was 0.27 (95% CI 0.13 to 0.50). The change in online pharmacy uk generic interstitial cystitis score over the first 12 weeks of treatment was 0.17 (95% CI 0.03 to 0.33) and the change in interstitial cystitis score over the last 12 weeks of treatment was 0.26 (95% CI 0.12 to 0.37). There were no between-group differences in the inflammatory bowel disease score or the interstitial cystitis score. The safety of both treatment groups at any time point was assessed by adverse events. The incidence of events was lower for nortriptyline. The incidence of all adverse events was similar in the two groups. There were no serious adverse events reported in the trial. Amitriptyline was associated with less adverse events than nortriptyline.